Endocrine Abstracts

Primary hyperparathyroidism (PHPT) is frequently diagnosed as an incidental finding of hypercalcemia. Overt bone disease (osteitis fibrosa cystica or brown tumor), with history of pathologic fractures is a rare presentation.A 48-year-old woman was admitted in with pain in the right thigh after a trivial fall. She also complained of generalized weakness and lethargy over the last 2 years. Her medical history mention multiple bone fractures in the last 6 y...

Introduction: Bariatric surgery is associated with improvement and often resolution of type 2 diabetes mellitus (T2DM). Our aim was to compare the effects of gastric banding (GB) and gastric bypass (GBP) in glucose homeostasis in obese patients with T2DM.Methods: From 1995 to 2011, 83 diabetic patients underwent bariatric surgery at our hospital: 37 underwent GB (73% females, mean age 48.3±9.2) and 46 underwent GBP (82.6% females, mean age ...

-Diana Borges Duarte and Francisca Puga are joint first authors and contributed equallyBackground: As therapeutic options improve for Cushing’s disease (CD), most patients can now achieve control or cure of hypercortisolism. However, persistent complaints are often reported. Evaluation of health-related quality of life (HR-QoL) can highlight impairments beyond the stricter clinical aspects. Our aim was to evaluate HR-QoL with a specific focus on men...

Introduction: Primary hyperaldosteronism is a known cause of arterial hypertension, classically with hypokalaemia. About 30–40% of the cases are caused by unilateral aldosterone-producing adenoma, and the recommended treatment is adrenalectomy. Hypoaldestoronism is an uncommon complication of unilateral adrenalectomy, but it can be life-threatening. We present a case of severe hypoaldosteronism after unilateral adrenalectomy for the treatment of primary aldosteronism....

Background: The lack of circadian rhythm is a marker of Cushing’s syndrome (CS). Therefore, salivary cortisol rhythm has been suggested for studies on the hypothalamic–pituitary–adrenal (HPA) axis. Late-night salivary cortisol has been used recently by many centers as a first line diagnostic test for CS, yet its accuracy is still on debate.Aim: To evaluated the performance of morning and late night salivary cortisol in patients with CS and...

Introduction: Myxedema coma is the ultimate stage of severe long-standing hypothyroidism, representing a true endocrinological emergency. Many precipitating factors have been identified, including the initiation of certain drugs.Case report: An 89-year-old woman was admitted to our emergency department due to an inaugural seizure. There was a history of progressive functional deterioration in the last 7 weeks, short after being diagnosed with lymph node ...

Idiopathic congenital hypogonadotropic hypogonadism (CHH) is a rare reproductive disorder that is primarily caused by a gonadotrophin-realising hormone (GnRH) deficiency. When CHH is associated with hyposmia or anosmia is designated by Kallmann Syndrome (KS). This syndrome is a genetic disorder with significant genetic heterogeneity that may present as a sporadic or familial case, following autosomal dominant, autosomal recessive, or X – linked recessive modes of inherita...

Introduction: Thionamides are important drugs in the treatment of hyperthyroidism. Despite that, they can be associated with rare but serious complications, which require drug discontinuation.Case report: Sixty-five-year-old woman with Graves’ disease, treated in 2002 with methimazole and in remission until 2012. Recurrence of Graves’ disease was diagnosed in March 2012 and she was started on propylthiouracil (PTU) 150 mg per day. She presented...

Introduction: Patients with psychotic or depressive disorders have an increased risk of developing metabolic syndrome, not only because of their unhealthy lifestyle (sedentary habits, inadequate diet and smoking) but also because of the negative impact of antipsychotic agents (specially clozapine and olanzapine) on several metabolic features. These include overweight/obesity, dyslipidemia, development of new-onset type 2 diabetes, worsening of pre-existing diabetes and diabeti...

Necrotizing fasciitis is a rare infection of the soft tissues with consequent necrosis of fascial planes and surrounding tissues. If misdiagnosed or not properly treated it can be fatal. It typically follows trauma and it have already been described after intramuscular or intravenous injection of insulin.The authors present a case of a 24-year-old man, with type 1 diabetes mellitus for more than ten years, admitted to the emergency room for diabetic keto...